When a pearl with a sinister reputation for causing misfortune to its owners is stolen from a museum by a master criminal because of Sherlock Holmes' show-boating, he is naturally obliged to find it. Soon, he learns of a series of brutal murders that seemed to have been commited by a malevolent man mountain known only as the Creeper. Now, Holmes must deal with the seemingly overwhelming menace of this man and his boss in order to retrieve the pearl.